Details
Gastroenterology and Hepatology
Bench to Bedside|
149,79 € |
|
| Verlag: | Springer |
| Format: | |
| Veröffentl.: | 14.05.2024 |
| ISBN/EAN: | 9789819992874 |
| Sprache: | englisch |
Dieses eBook enthält ein Wasserzeichen.
Beschreibungen
The book aims to be a handy compendium to the very voluminous texts of gastroenterology and hepatology existing in the knowledge market and provides the reader with an easy understanding of the bench knowledge (basic sciences) as they apply to bedside practice (clinical gastroenterology). With introduction and contributions from Prof Eamon Quigley, Former president of World Gastroenterology Organization and American College of Gastroenterology, the book covers the recent advances in the basic sciences that form an important pillar of the knowledge, thereby linking basic sciences such as anatomy, physiology, biochemistry, molecular medicine, etc. to clinical conditions, diseases and new therapeutic approaches in gastroenterology and hepatology. The book is written in a simple easy to read format, with a lot of diagrams and flowcharts, making it a handy guide. It also discusses in-depth about very common clinical conditions encountered in hospital settings such as ulcerative colitis, pseudomembranous colitis, colonic cancer, amebiasis, and various other syndromes and diseases. This book is a useful read for fellows and trainees in Gastroenterology and Hepatology, as well as gastroenterologists, hepatologists and physicians interested in digestive disorders.
<div>Section 1. Esophagus</div><div><br></div><div><br></div><div><br></div><div> A. Anatomy /Histology/Embryology</div><div>1. Lower Esophageal Sphincter </div><div>2. Barret’s esophagus</div><div>3. Webs, rings, diverticulae in esophagus</div><div>4. Cross sectional anatomy of esophagus: Tumor staging</div><div>5. Esophagus in portal hypertension </div><div>6. Tracheosophageal fistula</div><div> B. Physiology</div><div> 7. Acid clearance mechanism and defects in GERD</div><div> 8. TLESR</div><div> 9. Neurophysiological basis of esophageal peristalsis [normal manometry values</div><div> C. Genetics</div><div> 10. Genetic polymorphisms in GERD</div><div> 11.Biomarkers in Barret’s esophagus</div><div> D. Pathology</div><div> 12. Pathogenesis of achalasia cardia </div><div> 13. Eosinophilic esophagitis: histopathology difference from reflux esophagitis</div><div> E. Pharmacology</div><div> 14. Drugs acting on the LES</div><div> </div><div><br></div><div><br></div><div><br></div><div>Section 2. Stomach</div><div><br></div><div><br></div><div><br></div><div>A. Anatomy and physiology</div><div>1. Cross sectional anatomy of stomach</div><div>2. Innervationof stomach- Types of vagotomy</div><div>3. Post GJ/gastrectomy anatomy</div><div>4. Parietal cell and the proton pump</div>5. Chief cell<div>6. Enterochromaffin cells in stomach</div><div>7. Fundic gland: histology</div><div>8. Pyloric glands: histology</div><div>9. Gastric pacemaker</div><div>10. Blood supply –Arterial, venous supply of stomach and GE junction</div><div>11. Lymphatic drainage of stomach</div><div>12. Gastric volvulus</div><div>13. Intestinal metaplasia and atrophic gastritis</div><div>14. Gastric bed/ Lesser sac/Foramen of Winslow</div><div>B. Physiology</div><div> 15. Gastric mucosal defense and its breakdown in peptic ulcer</div><div> 16. Gastric proton pump </div><div> 17. Neurohormonal control of gastric acid secretion</div><div> 18. Gastric motility- Difference in fundus and body motility</div><div> 19. Leptin</div> 20. Motilin<div> 21. Physiological basis of breath tests for H.Pylori</div><div>C. Genetics</div><div> 22. H.Pylori virulence factors-cag, vac genes</div><div> 23.Host genetic polymorphisms and outcome of H.Pylori infection</div> 24. Host genetic polymorphisms and response to PPI<div> 25. c-kit mutation and response to therapy in GIST</div><div> D.Pathology</div><div> 26. Molecular pathogenesis of gastric cancer [Corea’s hypothesis] </div><div> 27.Pathogenesis of H.pylori associated gastric lymphoma</div><div> 28. NSAID associated gastric mucosal injury</div><div> 29. Autoimmune gastritis</div><div> 30. Granolomatosis gastritis</div><div> E. Microbiology</div><div> 31. H.Pylori- structure, stains for H.pylori</div><div> F. Pharmacology</div><div> 32. PPI/ H2 blockers</div><div> 33. Dopamine antagonists</div><div> 34. Serotonin antagonists</div><div> </div><div><br></div><div><br></div><div><br></div><div> Section 3. Small intestine</div><div><br></div><div><br></div><div><br></div><div> A. Anatomy/ Histology/Embryology</div><div>1. Development of small intestine and malrotation</div><div>2. Meckel’s diverticulum</div><div>3. Neural plexuses: Meissner’s/Aeurbach’s plexus</div><div>4. Villous anatomy</div><div>5. Microvilli</div><div>6. Intraepithelial lymphocyte</div><div>7. Brunner’s gland </div><div>8. M cells</div><div>9. Paneth cells</div><div>10. Zona occludens</div><div>11. Toll like receptors</div><div>12. Intestinal stem cells</div><div> B.Physiology</div><div> 13. MMC</div><div> 14.Intestinal Pacemaker</div><div> 15.Intestinal Permeability</div><div> 16.Small Bowel Permeability (SIP)</div><div> 17. Mucosal Defence</div><div> 18. Immunoglobulin A</div><div> 19. Defensins</div><div> 20. Enterokinase</div><div> 21. Cholecystokinin</div><div> 22. Secretin</div><div>23.Incretins</div><div>24. Peptide YY- ileal brake</div><div>25. Brain gut axis</div><div> C.Biochemistry </div><div> 26. Carbohydrate digestion </div><div> 27. Protein digestion</div><div> 28. Lipid digestion</div><div> 29. Vitamin B 12 absorption</div><div> 30.Iron absorption and metabolism</div><div> 31. Copper absorption</div><div> 32. Vitamin D metabolism</div><div> 33.Bile acid transport: Enterohepatic pathway</div><div> 34. Cholestrol metabolism</div><div> 35.D-Xylose test</div><div> 36. Vande Krammer test</div><div> 37. Breath tests for malabsorption-physiological basis</div><div> 38. Breath tests for SIBO-physiological basis</div><div> 39. Intestinal adaptation </div><div> D. Pathogenesis</div><div> 40. Protein losing enteropathy</div><div> 41.Eosinophilic gastroenteritis</div><div> 42.Celiac sprue</div><div> 43. Tropical sprue</div><div> 44. Intestinal tuberculosis</div><div> 45. SIBO</div><div> 46.Short gut syndrome</div><div> 47. Radiation enteritis</div><div> 48.Indeterminate colitis</div><div> 49. Pathogenesis of IBD</div><div> E. Microbiology</div><div>50. Normal gut microbiota</div><div>51. Lifecycle of parasites</div><div>52. Bacterial toxins causing diarrhea</div><div>53. Opportunistic pathogens in HIV patients</div><div>54.ASCA and ANCA: Role in IBD</div><div> F. Pharmacology</div><div>55.Probiotics</div><div>56. ORS-New Vs old; super ORS</div><div>57.Zinc and its role in small intestinal diseases</div><div>58. Green banana diet</div><div>59. Vaccines for intestinal infection</div><div>60. Enteral nutrition-types and indications</div><div>61. Immunonutrition</div><div>62. 10.5-ASA preparation and small intestinal release</div><div>63. TPMT assay and azathioprine metabolism</div><div>64. Biologicals in I BD</div><div>65. Methotrexate and folic acid</div><div> G. Genetics</div><div> 66. CARD/ NOD genes</div><div> 67. Genetics in IBD/IBD genes -Indian scenario </div><div> 68. Lactase genes</div><div><br></div><div><br></div><div><br></div><div>Section 4. Large intestine</div><div><br></div><div><br></div><div><br></div><div> A. Anatomy/ Histology/Embryology</div><div>1. Anal sphincters</div><div> 2. Dentate line </div><div> 3. Rectal folds (Valves of Houston) </div><div> 4. SRUS-Histopathology</div><div> 5. Adenomatous polyps- Types and significance</div><div> 6. Juvenile and hamartomatous polyps</div><div> B. Physiology</div><div>7. RAIR</div><div> 8. Fluid handling by intestine</div><div> 9. Colonic motility</div><div>10. Defecation-mechanism</div><div>11. Intestinal fistulas</div><div> C. Biochemistry</div><div>12. Short chain fatty acids</div><div>13. Fecal occult blood test- Types, limitations</div><div> D. Pathogenesis</div><div>14. Ulcerative colitis</div><div>15. Pseudomembranous colitis</div>16. Molecular pathogenesis of colonic cancer<div>17. Amebiasis</div><div>18. Microscopic colitis</div><div> 19. Newer concepts in pathogenesis of IBS</div><div>20. Montreal classification of IBD</div><div>21. Pathogenesis of pseudo-obstruction</div><div><br></div><br><div><br></div><div>Section 5 . Liver</div><div><br></div><div><br></div><div><br></div><div> A. Anatomy/Histology/ Embryology</div><div>1. Hepatocyte</div><div>2. Cholangiocyte</div><div>3. Ito cell</div><div>4. Stellate cell</div><div>5. Hepatic stem cell</div><div>6. Kupffer cells</div><div>7. Hepatitis B- structure and replication</div><div>8. Hepatitis C –structure and replication</div><div>9. Hepatitis E- structure</div><div>10. Hepatic sinusoid</div><div>11. Venous drainage of liver- importance in Budd Chiari syndrome</div><div>12. Ligaments of liver, surface anatomy of liver</div><div>13. Segments of liver</div><div> 14 .HBV mutants</div><div>15. IL-28B polymorphism and HCV</div><div> B.Physiology</div><div> 16. Bilirubin metabolism and congenital disorders</div><div> 17. Bile salt metabolism-enterohepatic shunts, congenital disorders</div><div> 18. Liver as an immunological organ</div><div> 19. Ammonia handling in liver, kidney, brain, muscles</div><div> 20. Ethanol metabolism</div><div> 21. Aminoacids- Branched chain : relevance in liver disease</div><div> 22. Urea cycle and congenital defects</div><div> 23. Eneterohepatic Circulation</div><div> C. Pathology</div><div> 24. Necroinflammatory and fibrosis scores</div><div> 25. Pathogenesis of alcoholic liver disease</div><div> 26. NAFLD-Pathogenesis</div><div> 27. Wilson’s disease</div><div> 28. Hemochromatosis</div> 29. Glycogen storage disorders<div> 30. HCC-molecular pathway</div><div> 31. Hepatic fibrosis- pro and antifibrotic mechanisms</div><div> 32. Hepatic encephalopathy- pathogenesis</div><div> 33. HRS- pathophysiology</div><div> 34. Ascites in liver disease – pathogenic mechanism</div><div> 35. NCPF: pathogenesis</div><div> 36. EHPVO: pathogenic mechanisms</div><div> 37. Pathogenesis of portal hypertension in cirrhosis – role of structural and functional reasons for portal hypertension </div><div> 38. Pathogenesis of hepato-pulmonary syndrome </div><div> 39. Pathogenesis of ALF </div><div> 40. Endocrine complications in cirrhosis </div><div> D. Microbiology</div><div> </div><div> 41. Genotyping methods</div><div> 42. ELISA </div><div> 43. HBV life cycle</div><div> 44. HCV replicon</div><div> 45. Malarial, enteric, dengue hepatopathy</div><div> 46. Mechanisms of HBV and HCV related HCC</div><div> 47.HCV and steatosis</div><div> </div><div> E. Pharmacology</div><div> 48. Interferons</div><div> 49 Ribavirin</div><div> 50. Eltrombopag</div><div> 51. Sorafenib</div><div> 52. Nucleoside analogues/nucleotide in HBV therapy</div><div> 53. L-Ornithine L- Aspartate</div><div> 54. Lactulose and other ammonia lowering agents</div><div> 55. Somatostatin analogues</div><div> 56. Role of viral kinetics in HCV treatment</div><div> 57. Role of HBsAg titre in HBV treatment</div><div> 58. Side effects of oral antiviral therapy and its pathogenesis</div><div><br></div><div> </div><div><br></div><div>Section 6. Bile duct, Gall bladder and Pancreas</div><div><br></div><div><br></div><div><br></div><div> A. Anatomy/ histology/ embryology</div><div>1. Pancreas development- Pancreas divisum, Annular pancreas, Ducts of Morgagani, Santorini</div><div>2. Choledochal cyst- Todani classification, types</div><div>3. Lesser sac anatomy-pancreatic pseudocyst</div><div>4. Sphincter of Oddi </div><div>5. Pancreatic stellate cells</div><div>6. Pancreatic stem cells </div><div>7. Pancreas- endocrine functions- Pancreatic neuroendocrine tumors</div><div> B. Physiology</div><div> 8. Bile production- bile acid dependent and -independent mechanisms</div><div> 9. Gallbladder bile Vs duodenal bile- changes incompositon</div><div> 10. Neurohormonal control of pancreatic secretion</div><div> 11. Neurohormonal control of biliary secretion</div><div> 12. Normal pressures in pancreatic and bile ducts</div> 13. Pancreatic enzymes- functions and feedback regulation<div> C. Pathology</div><div> 14. Microlithiasis</div><div> 15. Gallstone formation- supersaturation, nucleation, gallbladder dysmotility</div><div> 16. Gallstone- types and composition</div><div> 17. Pathophysiology of alcoholic chronic pancreatitis</div><div> 18. Pathophysiology of acute pancreatitis</div><div> 19. Pancreatic malignancy-molecular mechanism</div><div> 20. Cystic neoplasms of pancreas-Difference from pseudocyst</div><div> 21. Autoimmune pancreatitis</div><div> 22. Gallbladder carcinoma- etiopathogenesis</div> 23. PSC<div> 24. PBC</div><div> 25. Pain in chronic pancreatitis- pathophysiology</div><div> D. Pharmacology</div><div> 26.Octreotide</div><div> 27. Pancreatic enzyme supplements</div><div> 28. Ursodeoxycholic acid</div><div> 29. Statins</div> <div><br></div><div> E. Genetics</div><div> 31. Genes in chronic pancreatitis with relevant Indian data</div><div> 32. Genetic polymorphisms in gallstone disease</div><div><br></div><div><br></div><div><br></div><div> </div><div><br></div><div><br></div><div> Section 7. Miscellaneous</div><br><div> </div><div> 1. SiRNA</div><div> 2. Genetics of celiac disease</div><div> 3. Cannabanoid receptors</div><div> 4. Cadherins</div><div> 5 . Carcinoids in GI / Carcinoid syndrome</div><div> 6. CMV disease in GI and Liver</div><div> 7. Role of Integrins: development of biologics like natalizumab</div><div> 8. Wnt: GI Stem cells B-catemin</div> 9. Hedgehog: role in pancreas<div> 10. EGFR/ receptor tyrosine kinases/ K Ras</div><div> 11. IFN signalling: antiviral immunity</div><div> 12. Overview of innate immunity</div><div> 13. T cell subsets: Th1, Th2, Th17</div><div> 14. B cells / Eosinophils</div><div> 15. TGF B pathway</div><div> 16. G Coupled protein receptors</div><div> 17. Small GTPases : Rho/ Rac/ CDC 42</div><div> 18. Angiogenesis</div><div> 19. GWAS</div><div> 20.Transcription factors</div><div> 21. Oncogenes</div><div> 22.Tumor suppressor genes</div><div> 23.Telomerase</div><div> 24. Liver nuclear receptors</div><div> 25. Role of Vit D in GI diseases</div><div> 26. Apoptosis</div><div> 27. Gene therapy in Gastroenterology</div><div> 28. Stem cells in Gastroenterology</div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div>
<p>Dr.Gourdas Choudhuri, MD (Medicine), DM(Gastroenterology), FACG, FAMS, FICP, FRCP, Chairman and Head, Department of Gastroenterology and Hepato-biliary Sciences, Fortis Memorial Research Institute, Gurgaon, Haryana, India</p>
<p>Dr. A. C. Anand MD (Medicine), DM (Gastroenterology), FICP, FSGEI, FRCP(London), FRCP (Edinburg), FACP, FACG, FAMS, Professor and Head, Department of Gastroenterology & Hepatology <br> Kalinga Institute of Medical Sciences, Bhubaneshwar, India</p>
<p>Dr Piramanayagam P, MD (Medicine), DM Gastroenterolgy), Consultant, Department of Gastroenterology, Apollo Hospitals 21, Greams Lane, Off Greams Road Chennai, India</p>
<p>Dr. A. C. Anand MD (Medicine), DM (Gastroenterology), FICP, FSGEI, FRCP(London), FRCP (Edinburg), FACP, FACG, FAMS, Professor and Head, Department of Gastroenterology & Hepatology <br> Kalinga Institute of Medical Sciences, Bhubaneshwar, India</p>
<p>Dr Piramanayagam P, MD (Medicine), DM Gastroenterolgy), Consultant, Department of Gastroenterology, Apollo Hospitals 21, Greams Lane, Off Greams Road Chennai, India</p>
The book aims to be a handy compendium to the very voluminous texts of gastroenterology and hepatology existing in the knowledge market and provides the reader with an easy understanding of the bench knowledge (basic sciences) as they apply to bedside practice (clinical gastroenterology). With introduction and contributions from Prof Eamon Quigley, Former president of World Gastroenterology Organization and American College of Gastroenterology, the book covers the recent advances in the basic sciences that form an important pillar of the knowledge, thereby linking basic sciences such as anatomy, physiology, biochemistry, molecular medicine, etc. to clinical conditions, diseases and new therapeutic approaches in gastroenterology and hepatology. The book is written in a simple easy to read format, with a lot of diagrams and flowcharts, making it a handy guide. It also discusses in-depth about very common clinical conditions encountered in hospital settings such as ulcerative colitis, pseudomembranous colitis, colonic cancer, amebiasis, and various other syndromes and diseases. This book is a useful read for fellows and trainees in Gastroenterology and Hepatology, as well as gastroenterologists, hepatologists and physicians interested in digestive disorders.
Connects the knowledge of basic sciences to clinical conditions and diseases in gastroenterology and hepatology. Serves as a -easy-to-read and understand handbook for fellows and young clinicians Discusses about the various diseases commonly encountered in hospital settings
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